Protein name:
Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) ;
Alternative:
C/EBP-related ATF (C/ATF) ;Activating transcription factor 4 ;Tax-responsive enhancer element-binding protein 67 homolog (TaxREB67 homolog) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2. Interacts with the N-terminal region of CEP290 (By similarity). Binds DNA as a homo- and heterodimer. Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors. Forms a heterodimer with TXLNG in osteoblasts. Interacts with NEK6.
Function:
Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer.
Subcellular Location:
Cytoplasm
Cell membrane
Nucleus
Cytoplasm
cytoskeleton
centrosome
Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Co-localizes with NEK6 in the centrosome.
Protein Attributes:
50:
MTEMSFLNSE | VLAGDLMSPF | DQSGLGAEES | LGLLDDYLEV | AKHLKPHGFS |
100:
SDKAGSSEWP | AMDDGLASAS | DTGKEDAFSG | TDWMLEKMDL | KEFDFDALFR |
150:
MDDLETMPDE | LLTTLDDTCD | LFAPLVQETN | KEPPQTVNPI | GHLPESLIKV |
200:
DQVAPFTFLQ | PFPCSPGVLS | STPEHSFSLE | LGSEVDISEG | DRKPDSAAYI |
250:
TLIPPCVKEE | DTPSDNDSGI | CMSPESYLGS | PQHSPSTSRA | PPDNLPSPGG |
300:
SRGSPRPKPY | DPPGVSLTAK | VKTEKLDKKL | KKMEQNKTAA | TRYRQKKRAE |
349:
QEALTGECKE | LEKKNEALKE | KADSLAKEIQ | YLKDLIEEVR | KARGKKRVP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
Rat
ELISA Kit for Mouse cAMP-dependent transcription factor ATF-4
ELISA Kit for Mouse cAMP-dependent transcription factor ATF-4
ELISA Kit for Mouse cAMP-dependent transcription factor ATF-4
ELISA Kit for Mouse cAMP-dependent transcription factor ATF-4
CLIA Kit for Mouse cAMP-dependent transcription factor ATF-4
CLIA Kit for Mouse cAMP-dependent transcription factor ATF-4
CLIA Kit for Mouse cAMP-dependent transcription factor ATF-4
CLIA Kit for Mouse cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Polyclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Monoclonal Antibody for Mouse cAMP-dependent transcription factor ATF-4
Protein for Mouse cAMP-dependent transcription factor ATF-4
Protein for Mouse cAMP-dependent transcription factor ATF-4
Protein for Mouse cAMP-dependent transcription factor ATF-4
Protein for Mouse cAMP-dependent transcription factor ATF-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBUNIT;SUBCELLULAR LOCATION
tissue :
Adipocyte .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
CD-1 .
tissue :
Embryo .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
BALB/c .
strain :
C57BL/6J .
strain :
NOD .
tissue :
Lung .
tissue :
Spinal cord .
tissue :
Spleen .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Eye .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TXLNG
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SATB2
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;INTERACTION WITH FOXO1;FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
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Cell153:840-854(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;UBIQUITINATION;PHOSPHORYLATION AT THR-212; SER-218; SER-223; SER-230; SER-234 AND SER-247;MUTAGENESIS OF THR-212; SER-218; SER-223; SER-230; SER-234 AND SER-247